Publications
Dissertations
1. A KAP study of birth and death registration in a suburb of Port Harcourt, Rivers State, Nigeria, 1991. Submitted to Department of Preventive and Social Medicine, University of Port Harcourt, as Part of Requirements for the MBBS degree.
2. The antiulcer effects of Enantia chlorantha in rats, 2002. MSc dissertation submitted to the Department of Pharmacology, University of Lagos.
3. The prevalence of metabolic syndrome in adult subjects attending family medicine clinics in Rivers State, Nigeria, 2007. MD dissertation submitted to the College of Health Sciences, University of Port Harcourt.
1. Dede, EB and Siminialayi, IM. Possible mechanism of tachyphylaxis of guinea pig ileum isolated tissue to nicotine. Journal of Applied Science and Environmental Management, 2000; 4:33-38
2. Dede, EB and Siminialayi, IM. Electroencephalograhic study of the interaction between dichlorvos and lindane in the rat brain. Nigerian Journal of Neuroscience, 2001; 4:21-26
3. T Kurubo-Owiye, DV Dapper and IM Siminialayi. Visual acuity pattern of school age children in Port Harcourt, Nigeria. Nigerian Journal of Neuroscience, 2002; 5:17-24
4. DV Dapper, IM Siminialayi and T Kurubo-Owiye. Defects of colour vision in undergraduate students of the University of Port Harcourt, Nigeria. Nigerian Journal of Neuroscience, 2002; 5:25-28
5. IM Siminialayi and EO Agbaje. Gastroprotective effects of the ethanolic extract of Enantia chlorantha in rats. West African Journal of Pharmacology and Drug Research, 2004; 20(1&2):35-38
6. IM Siminialayi and EO Agbaje. The possible mechanism of antiulcer effects of Enantia chlorantha in rats. West African Journal of Pharmacology and Drug Research, 2004, 20(1&2);39-43
7. IM Siminialayi and PC Emem-Chioma. Glucocorticoids and the insulin resistance syndrome. Nigerian Journal of Medicine, 2004, 13(4):330-335
8. IM Siminialayi and PC Emem-Chioma. Type 2 Diabetes Mellitus: A Review of Pharmacological Treatment. Nigerian Journal of Medicine, 2006, 15(3):207-214
9. PC Emem-Chioma and IM Siminialayi. Prevalence of Dyslipidaemia in Adult Patients Attending Outpatient Clinic in a Rural Hospital in Rivers State, Nigeria. The Nigerian Health Journal, 2006; 6(1&2): 363-368
10. Siminialayi IM, Emem-Chioma PC and Dapper DV. The Prevalence of Obesity as Indicated by BMI and Waist Circumference among Nigerian Adults Attending Family Medicine Clinics in Rivers State. Nigerian Journal of Medicine, 2008; 17(3): 340-345
11. Ejebe DE, Siminialayi IM, Nwadiuto C, Emudainohwo JOT, Akonoghrere R, Onyesom I , Ovuakporaye SI, Ojieh AE, Olise CC. Effects of ethanol extract of leaves of Helianthus annus on the reproductive system of male Wistar rats: testicular histology, epididymal sperm properties and blood levels of reproductive hormones. Biomedical and Pharmacology Journal, 2008; 1(1): 65-78
12. DV Dapper, IM Siminialayi and OO Ebong. Further antiplasmodial effects of the aqueous extract of Cymbopogon citratus stapf (lemon grass) against Plasmodium berghei in Swiss albino mice. Asian Pacific Journal of Tropical Medicine, 2008; 1(3): 7-12.
13. Siminialayi IM, Emem-Chioma PC. Metabolic syndrome in a rural Nigerian community: is central obesity always the key determinant? The Nigerian Health Journal 2008;(3-4): 29-34.
14. DV Dapper, CA Nwauche and IM Siminialayi. Haematologic Reference Values for Pre-Primary and Primary School Aged Children in Port Harcourt, Nigeria. Nigerian Journal of Clinical Practice, 2009; 12(3): 262-267.
15. Ejebe DE, Siminialayi IM, Emudainohwo JOT, Ovuakporaye S.I., Ojieh AE, Akonoghrere R, Odokuma IE and Ahatty GC. An improved technique for oral administration of solutions of test substances to experimental rats using mediflon/medicut intravenous cannula. African Journal of Biotechnology, 2009; 8(6): 960-964.
16. Amadi CN, Odigie JO and Siminialayi IM. The effects of methanol extract of Cleistopholis patens on the reproductive system of female Wistar rats. Asian Pacific Journal of Tropical Medicine, 2009; 2(1): 1-6
17. Amazu LU, Ebong OO, Azikiwe CCA, Unekwe PC, Siminialayi IM, Nwosu PJC, Ezeani MC, Obidiya OS and Ajugwo AO. Effects of methanolic seeds extract of Carica papaya on Plasmodium berghei infected mice. Asian Pacific Journal of Tropical Medicine, 2009; 2(3):1-6
18. Siminialayi IM, Emem-Chioma PC, Odia OJ. Relative risk of metabolic syndrome components in Nigerians: the adult treatment panel III definition. Port Harcourt Medical Journal, 2009; 3: 302-311.
19. Azikiwe CCA, Amazu LU, Unekwe PC, Nwosu PJC, Ezeani MC, Siminialayi IM, Obidiya SO, Arute JE. Antidiabetic fallacy of Vernonia amygdalina (bitter leaves) in human diabetes. Asian Pacific Journal of Tropical Medicine, 2009; 2(5):54-57.
20. JO Odigie and IM Siminialayi. Medical waste management at the University of Port Harcourt Teaching Hospital. Port Harcourt Medical Journal, 2009; 4:23-28.
21. SC Iwuji, EO Agbaje, NG Ekeh and IM Siminialayi. Hepatic safety of Enanthia chlorantha used as antimalarial: an animal study. African Journal of Medical Physiology, Biomedical Engineering & Science, 2009;1:71-74
22. Wariso KT, Siminialayi IM and Odigie JO. Pattern and antibiogram of urinary tract infection at the University of Port Harcourt Teaching Hospital. Asian Pacific Journal of Tropical Medicine, 2010; 3(1): 1-5
23. IM Siminialayi, RI Okafor and PC Emem-Chioma. Effect of subacute administration of protein powder on the histology of rat kidneys. Port Harcourt Medical Journal, 2010; 4: 294-300
24. IM Siminialayi, PC Emem-Chioma and OJ Odia. Prevalence of metabolic syndrome in suburban and urban Rivers State: adult treatment panel III and IDF definitions. Nigerian Postgraduate Medical Journal, 2010; 17(2): 147-153.
25. JO Odigie and IM Siminialayi. Perception and attitude of theatre staff to preoperative HIV screening. Asia Pacific Journal of Tropical Medicine, 2010; 3(2):145-147.
26. Ejebe DE, Siminialayi IM and Kagbo HD. Mass immunization of Nigerian children against paralytic poliomyelitis: a case for the review of current practice of too frequent administration of the Sabin vaccine. Medi-link Journal, 2010; 11(3); 40-41.
27. Ejebe DE, Siminialayi IM, Emudainohwo JOT, Ofesi U and Morka L. Analgesic and anti-inflammatory activities of the ethanol extract of the leaves of Helianthus annus in Wistar rats. Asian Pacific Journal of Tropical Medicine, 2010; 3(5): 341-347.
28. Ejebe DE, Siminialayi IM, Emudainohwo JOT, Kagbo HD and Amadi P. Effects of Ethanol extract of leaves of Helianthus annus on the fecundity of Wistar rats. Asian Pacific Journal of Tropical Medicine, 2010; 3(5):412-420.
29. Koroye OC, Siminialayi IM and Etebu EN. Effects of oral administration of Aloe vera plus on the heart and kidney: a subacute toxicity study in rat models. The Nigerian Health Journal 2010; 10(1-2): 22-27.
30. SC Iwuji, KI Nkuma-Udah, GO Adeoye, NG Iwuji, GC Iwueke and IM Siminialayi. Insecticidal efficacy of lambdacyhalothrin, cyfluthrin, Orange peel oil and platostoma sp. Leaf extract on anopheles mosquitoes. International Journal of Natural and Applied Sciences, 2010; 6(3): 317-320.
31. Koroye OC, Siminialayi IM and Etebu EN. Effects of oral Aloe vera on the liver: a pharmacovigilance study in rats. West African Journal of Pharmacology and Drug Research, 2011; 26(1&2): 29-35.
32. PC Emem-Chioma, IM Siminialayi, and FS Wokoma. Prevalence of kidney disease in adults with metabolic syndrome. Saudi Journal of Kidney Diseases and Transplantation, 2011; 22(5): 949-954.
33. Amadi CN, IM Siminialayi and Orisakwe OE. Male Infertility and Herbal Supplements: an Update. Pharmacologia, 2011; 2: 323-348
34. Azikiwe CCA, Ifezulike CC, Siminialayi IM, Amazu LU, Enye JC and Nwakwunite OE. A comparative laboratory diagnosis of malaria: microscopy versus rapid diagnostic test kits. Asia Pacific Journal of Tropical Biomedicine, 2012; 2(4): 307-310.
35. Azikiwe CCA, Siminialayi IM, Brambaifa N, Amazu LU, Enye JC, Ezeani MC. Anticonvulsant activity of the fractionated extract of Crinum jagus bulbs in experimental animals. Asia Pacific Journal of Tropical Disease. 2012; S446-452
36. Amadi CN, Siminialayi IM, Roberts II and Orisakwe EO. Elemental impurities in registered herbal supplements in Nigeria: A look at mercury, antimony and tin. Rasayan Journal of Chemistry 2012, 5(2):220-228
37. Azikiwe CCA, Siminialayi IM, Brambaifa N, Ifezulike CC, Nwankwo MJ and Amazu LU. Selective antiseizure activity of synthetic morpholine in experimental animals. International Journal of Medicine and Medicinal Sciences, 2013; 3(4): 411-418
38. Effect of Aloe Vera gel extract on cadmium-induced high blood pressure. Isirima JC and Siminialayi IM. West African Journal of Pharmacology and Drug Research, 2012; 28:22-27.
39. JS Aprioku and IM Siminialayi. Maternal lead exposure and pregnancy outcome in Wistar albino rats. Journal of Environmental Health Sciences, 2013, 5(4): 2400-2407.
40. Shorinwa OA, Ebong OO, Obianime AW, Siminialayi IM. Acetone extract of Crinun jagus bulbs (Liliaceae): an acute and sub-chronic toxicological evaluation in albino rats. International Research Journal of Pharmacy, 2014, 5(7): 560-564.
41. Shorinwa OA, Ebong OO, Obianime AW, and Siminialayi IM. The effect of acetone extract of Crinun jagus bulbs on the histology of the kidney, liver and testis of albino rats. Peak journal of Medicinal Research, 2014, 2(4): 38-44.
42. Georgewill UO, Siminialayi IM. Disulfiram and copper gluconate in cancer chemotherapy: a review of the literature. Cancer Research, 2014, 2(5): 88-92.
43. Emem-Chioma PC, Akpa MR and Siminialayi IM. Hypertension in Rural Niger Delta of Nigeria: frequency and correlates. Journal of US-China Medical Science, 2014, 12: 18-19.
44. Okolo KO, Siminialayi IM and Orisakwe OE. Protective Effects of Pleurotus tuber-regium on Carbon- Tetrachloride Induced Testicular Injury in Sprague Dawley Rats. Front. Pharmacol., 2016, 7:480. doi: 10.3389/fphar.2016.00480
45. Udoh IE, Aprioku JS and Siminialayi IM. Acute and subacute toxicity evaluation of disulphide derivative of dihydroartemisinin. World Journal of Pharmaceutical Research, 2017, 6(01):77-95. DOI:10.20959/wjpr201701-7373
46. Siminialayi IM. The rising burden of non-communicable disease and food as medicine. Niger Delta Medical Journal 2017, 2(1): 19-36.
47. Udoh EU, Aprioku JS and Siminialayi IM. In-vivo Anti-tumor Evaluation of Dihydroartemisinin- Derived Endodisulphide on MNU-induced Liver Cancer in Sprague-Dawley Rats. International Journal of Tropical Disease & Health, 2017, 25(3): 1-13.
48. Akoko S, Siminialayi IM and Obianime AW. Reliability of some selected novel markers in detecting early renal dysfunction in HIV Patients on TDF regimen: a Nigerian study. International Journal of Public Heath, Pharmacy and Pharmacology 2017, 2 (2): 1-11.
49. Okolo KO, Siminialayi IM and Orish EO. Carbon tetrachloride induced hepatorenal toxicity in rats: possible protective effects of wild Pleurotus tuber-regium. International Journal of Phytomedicine and Phytotherapy 2017, 3:2 https://doi.org/10.1186/s40816-016-0040-5
50. Okolo KO, Orish EO and Siminialayi IM. Peurotus tuber-regium mushrooms in the diet of rats ameliorates reproductive and testicular injury caused by carbon tetrachloride. International Journal of Phytomedicine and Phytotherapy 2017, 3:4. https://doi.org/10.1186/s40816-017-0051-x
51. Onyewuchi CB, Aprioku JS and Siminialayi IM. Evaluation of ethanol bark extract of Moringa oleifera on reproductive biology of non-pregnant Wistar albino rats. Journal of Complementary and Alternative Medical Research 2018, 5(2): 1-7
52. Isirima Joshua Charles and Siminialayi Iyeopu Minakiri. Effect of the methanol leaf extract of Chromolaena odorata on blood lipids and the histology of the kidney in Salmonella type infected Wistar rats. International Journal of Contemporary Research and Review 2018, 9(4): BT20239-20250.
53. Shorinwa OA, Ebong OO, Obianime AW and Siminialayi IM. Evaluation of the in-vitro antioxidant and antiplasmodial activities of the acetone extract of Crinum jagus bulbs (Liliaceae) linn. International Journal of Pharmaceutical Sciences and Research 2018, 9(7): 1000-1009.
54. Isirima JC and Siminialayi IM. Evaluation of the antibacterial activity of Chromolaena odorata in Wistar rats and its chemical characterization. American Scientific Journal for Engineering, Technology and Sciences 2018, 42(10): 111-129.
55. Okolo KO, Orish EO and Siminialayi IM. Nephroprotective and antioxidant effects of Pleurotus tuber-regium on carbon tetrachloride induced nephrotoxicity in male Sprague Dawley rats. International Journal of Medicinal Mushrooms 2018. DOI. 10.1615/IntJMedMushrooms.2018026044.
56. Isirima JC and Siminialayi IM. Effect of Chromolaena odorata Extract on Hematotoxicity and Spleen Histopathology Induced by Salmonella typhi in Wistar Rats. Pharmacology & Pharmacy 2018, 9: 85-99. https://doi.org/10.4236/pp.2018.94007
57. Isirima JC and Siminialayi IM. Evidence of hypolipidaemic and gastro-intestinal histopathological moderation effect of Chromolaena odorata pretreatment in Salmonella typhi infected Wistar rats. International Journal of Innovative Research and Development 2018, 7(4):22-33. http://dx.doi.org/10.19044/esj.2018.v14n12p421
58. Isirima JC and Siminialayi IM. Evidence of hypolipidaemic and gastro-intestinal histopathological moderation effect of Chromolaena odorata pretreatment in Salmonella typhi infected Wistar rats. International Journal of Innovative Research and Development 2018, 7(4):22-33. http://dx.doi.org/10.19044/esj.2018.v14n12p421
59. Isirima JC and Siminialayi IM. Effect of Chromolaena Odorata on hepatotoxicology and histopathology in the liver induced by Salmonella typhi in Wistar rats. European Scientific Journal 2018, 14(12):421-436. DOI No. : 10.24940/ijird/2018/v7/i4/APR18014
60. Nwidu LL, Elmorsy E, Aprioku JS, Siminialayi IM and Carter WG. In vitro anticholinesterase and antioxidant activity of extracts of Moringa Oleifera plants from Rivers State, Niger Delta, Nigeria. Medicines 2018, 5, 71. Doi:10.3390/medicines5030071
58. Isirima JC and Siminialayi IM. Evidence of hypolipidaemic and gastro-intestinal histopathological moderation effect of Chromolaena odorata pretreatment in Salmonella typhi infected Wistar rats. International Journal of Innovative Research and Development 2018, 7(4):22-33. http://dx.doi.org/10.19044/esj.2018.v14n12p421
59. Isirima JC and Siminialayi IM. Effect of Chromolaena Odorata on hepatotoxicology and histopathology in the liver induced by Salmonella typhi in Wistar rats. European Scientific Journal 2018, 14(12):421-436. DOI No. : 10.24940/ijird/2018/v7/i4/APR18014
60. Nwidu LL, Elmorsy E, Aprioku JS, Siminialayi IM and Carter WG. In vitro anticholinesterase and antioxidant activity of extracts of Moringa Oleifera plants from Rivers State, Niger Delta, Nigeria. Medicines 2018, 5, 71. Doi:10.3390/medicines5030071